But however really and constantly inflammation may take place in fever, and in whatever intensity, and to whatever extent it may be carried, yet the inflammation is never pure or simple: the condition of the inflamed organs is never the same as that into which they are brought by mere phlegmasia: there is always inflammation, and _something else_: and if what we have so much insisted on be true, this must necessarily be the case, because the state of inflammation succeeds to another, a distinct, and a pre-existing condition of the system: that something else is the unknown, but the peculiar and specific affection of the nervous system, which has already been stated to be the invariable antecedent of whatever subsequent affection may take place. Thus this affection of the nervous system is not only the invariable antecedent of every other condition, but it is omni-present with every other condition, and its presence is a most powerfully influential presence; it operates at every instant, in every organ, and every function of the economy, although, as we have seen, its operation is peculiarly great, and, as far as we can perceive, specific in certain organs and functions. The combination of this nervous affection with inflammation, and the influence which this combination exerts over the inflammatory state, we express by saying that the inflammatory state in fever is modified: we see that inflammation is present, but we see that it is not the same as inflammation in a pure phlegmasia: we see, as has just been stated, that there is inflammation, and something else superadded; namely, a peculiar affection of the nervous system, which gives to the febrile inflammation a peculiar character, or which modifies it in a specific manner.