Pains in the loins and extremities were very marked in an individual of whom Serrurier remarks as follows:--“A patient whom I attended was reduced to a most dreadful state of marasmus, in consequence of nocturnal pollutions, determined by venereal excesses. I prescribed a tonic mode of treatment, and varied it in every form; but the patient died, after four months of frightful pains in the loins and articulations.” There was apparently, in this case, an affection of the lumbar part of the medulla, or of its membranes. A similar malady existed, probably, in a man whose case was published by Hattè, and who was affected, in consequence of excesses in coition, with a lumbago, which alternated with satyriasis. There is no doubt, in regard to the affection of the spinal marrow, in the following case related by Van Swieten:--“For three years” says he, “I used all the aids of medicine for a young man, who, in consequence of onanism, was affected with general wandering pains--with a sensation, sometimes of heat, sometimes of cold, which was extremely unpleasant, over the whole body, but particularly in the loins. After a time, these pains diminished slightly; and then the thighs and legs were so cold, that although these parts, on being touched, seemed to preserve their natural heat, yet he was constantly warming himself at the fire, even during the warmer days of summer. I observed, particularly, a constant rotation of the testicles in the scrotum; and the patient felt a similar motion in the loins, which was very troublesome to him.” Was the spinal marrow perfectly healthy in the onanist who wrote to Tissot the following:--“My nerves are extremely weak. My hands have no strength: they tremble constantly, and perspire freely. I have violent pains in my stomach, arms, and legs; and sometimes in the kidneys, chest,” &c. Persuaded, also, from a great many cases, that most of the pains termed rheumatic are neuralgic, and that many neuralgias depend on an affection of the spinal marrow; I think there is reason to suspect this affection, whenever it is found in onanists. The following case, related by Dr. Bertini of Turin, presents, as a principal symptom, convulsive trembling of the lower extremities. The disease commenced, as is frequently the case, under the influence of an accidental cause; but when this had occurred, the patient presented for a long time symptoms of an affection of the medulla; and it is evident that their origin must be ascribed to onanism.