A shoemaker, twenty-four years old, of good constitution, who has always enjoyed good health, contracted the habit of masturbation at the age of sixteen years, and became so addicted to it, that he indulged seven or eight times a-day: his strength soon diminished, and he lost flesh and his color. After an interruption, caused by an acute disease, the patient resumed his fatal habit with the same earnestness. He finally became so weak; languid, and pale, that he was discharged from military service, in which he was inscribed. A little while afterward, this young man, who had never shown any symptoms of scrofula, presented scrofulous engorgements in the groins and axillæ, and swellings, with caries, in several phalanges of the fingers. At the same time, a singular phenomenon appeared: the hair, which was chestnut colored, came off; on growing again, it appeared of several colors: but after coming off once or twice, it resumed its natural shade. The patient continuing to indulge in onanism, finally became extremely weak, and was obliged to keep his bed. Marked symptoms of myelitis now appeared. The patient gradually lost the use of his lower limbs: first they became weak, and showed a disposition to be crossed; but finally wasted away, and lost the power of motion. He was now obliged even to be turned in bed, as he could not move. The articulation of the feet and knees became stiff and inflexible, and his legs were so much retracted, that the end of the foot only touched the ground, when the patient was placed in an erect position. The sensibility of the limbs, also, was as much affected as their motions; they were cold, numb, and even when pinched they were not painful. The general languor was increased every day. He suffered from thirst, dyspepsia, pains in the stomach, rumblings, night sweats, &c. At this period, the patient quitted a woman with whom he had lived for a year, and who, having but little inclination for coition, caused him to indulge in masturbation. The erections were frequent, powerful, short, and always terminated with a more or less abundant discharge of mucus from the urethra--perhaps, also from the prostate gland; or even the discharge might be of thin semen. After a while, the ejaculations were composed, instead of semen, of a half-clotted, blackish or yellowish blood: sometimes, as much as a tablespoonful was lost. These emissions were always painful, and were followed by extreme prostration.