The patient, notwithstanding the progress of these symptoms, continued to masturbate. Debility and pains in his loins extended into the abdominal limbs, and increased so much, that he was obliged to keep his bed: he could only lie on his left side; but in this position his motions were easy. The diminution in the natural heat, the livid color of the skin, the softness and flaccidity of the flesh, debility, loss of sleep and of flesh, thirst, constipation, &c., were added to the symptoms already mentioned. At the same time, a hard, indolent tumor, the size of a pullet’s egg, was formed at the lower part of the dorsal region. This tumor, which did not enlarge, evidently resulted from the prominence of the spinous processes, and consequently from a curve in the spine, which was doubtless caused by a softening of the bodies of the vertebræ. Nearly at the same period, there was developed, at the lower part of the sternum, a hard, indolent tumor; the color of the skin was unchanged: it gradually became the size of a nut, suppurated, and assumed the appearance of a scrofulous ulcer. The lymphatic ganglions of the neck, which were somewhat swelled, now returned to their natural size. The treatment was similar to that used in the former case, and was attended with the same result: the strength, bodily heat, and appetite returned. Finally, the patient was able to walk with crutches; and could stand, unsupported, for a few moments. The circumstances in this case are not detailed with sufficient accuracy, to enable us to follow exactly the cause of the symptoms. We would remark, however, that one of these seen first was the neuralgic pains, which extended from the loins into the lower extremities. Now, as this symptom belongs to irritation of the medulla or its membranes, more than to their compression, there is reason to think that this irritation preceded the curve of the spine. In this patient, also, as in the preceding case, the affection of the marrow had not so much influence in causing the destruction of the bodies of the vertebræ, as a disposition to caries--a disposition which was evidently increased by onanism, and which appeared at the same time in several bones. The following case, from Meyrieu, is not sufficiently detailed, to affect in any manner the question, how caries of the vertebræ is produced in onanists; but it is interesting, as it shows that the disease may extend to the soft parts which cover or are adjacent to the affected vertebræ.