D-- E--, five years old, and addicted to masturbation, after passing a part of the winter at the Hospital des Enfans, to be treated for scrofulous engorgements of the glands of the neck, was sent to the country in the spring. He had been there about three months, when he was suddenly affected with a contraction of the lower extremities. Examined the 5th of July, he complained neither of pain in the head nor spine. The digestive passages were in very good state; there was no derangement in the circulation or respiration; the muscles of the lower extremities were permanently rigid: the tension, however, was more marked in the adductors; for the patient constantly kept his knees crossed. There was no deviation in the vertebral column. Different remedies were employed, but without success; except a little improvement under the use of carbonate of iron. The legs and thighs of the patient could be flexed and extended with the hands; but he could neither flex them when extended, nor extend them when flexed. This child was cured in a singular manner. His state was as described, when, at the beginning of September, he was affected with symptoms of roseola. The contraction of the lower extremities disappeared, when the fever came on. The eruption went through its course, and the contraction of the limbs did not return. Thus, this disease, which had resisted several efficacious remedies, disappeared before another disease. The loss or debility of the external senses, particularly those of hearing and sight, when this state is the consequence of venereal excesses, often result, as may be seen in several of the cases above stated, from a disease of the brain. This organ was probably diseased in the old man whose case was mentioned by Réveillé Parise. This man was desirous of living with a young Italian girl, whose temperament was extremely ardent. He paid for his imprudence by blindness, which occurred in eight days, and which was followed by death. Sometimes, however, the eye alone is diseased: at least, the pathological state which it presents is unattended by any symptoms indicating an affection of the brain or its membranes. Many libertines present only an irritation of the conjunctiva and of the edge of the eyelids. It is a sort of chronic ophthalmia; their eyes are red, watery, fatigued, painful; and they cannot engage in the evening in any occupation, such as reading, which requires the attention to be confined to one object. Sometimes, a severe and deep-seated pain proves that, beside the outer parts of the eye, the interior of this organ is the seat of a severe irritation. Hoffmann has seen several cases of this. He cites that of a young man, who indulged in onanism from the age of fifteen to that of twenty-three. “His eyes and head were so weak,” says he, “that these organs were often affected with violent spasms, during the emission of semen. Whenever he attempted to read, he experienced a