Besides rachitis, caries, and tubercles, which have been mentioned, are the bones ever affected with any other disease, in consequence of venereal indulgences? The only case in point is that already mentioned,(p. 85) as reported by Serrurier, of a man who was reduced to a complete state of marasmus, in consequence of venereal excesses and nocturnal pollutions. In this man’s case, a remarkable circumstance occurred. Having attempted, a few days before death, to rest himself from the fatigues of the bed, by spending a few hours in the easy chair, he fractured the bone of his right thigh at its centre, merely by attempting to cross the right thigh on the left. Might not this disease, which is very rare, and is termed friability of the bones, be also caused by the excesses we have mentioned? These excesses, if accompanied by those of the table, or if indulged in under unfavorable circumstances, may be followed by acute, as well as by chronic affections, and particularly by fevers of a bad character. This result of excessive enjoyments is frequent; and cases of it have been seen by almost every physician. It was known to the ancients. Hippocrates gives the history of a young man of Melibœa, who, after indulging in women and wine, was attacked with all the symptoms of typhus fever. Bartholin knew a person, recently married, who was attacked, after conjugal excesses, with an acute fever, attended with great depression, sinking, nausea, immoderate thirst, &c. This patient was cured by rest and tonics. Hoffmann, who states this case, also mentions that of a man, who never indulged in venereal excesses without being attacked with fever, which continued several days. Tissot, in 1761 and 1762, knew two very healthy, strong, and vigorous young men, who were attacked, one the day after, and the other the second night of their marriage, with a very violent fever, preceded by no chill, pulse quick and hard, wakefulness, many slight convulsive motions, very great inquietude, and dry skin. The appearance of the second was very much altered, and he was troubled with dysuria. He first thought that an intemperate use of wine was in part the procuring part of these symptoms; but I was of a different opinion in regard to the second. They were cured at the end of two days. This circumstance added to the character of the disease, leaves no doubt of the cause. Sauvages admits, after Dellon, that a typhus of exhausted persons exists. The Portuguese term patients affected with this malady, _esfalfados_. The exhaustion caused by immoderate indulgence in venereal pleasures, says this author, is very common among the Indians. It is a continued fever, in which the pulse is sometimes full and strong, sometimes weak, and almost imperceptible. The urine is sometimes very red, but transparent; the skin is hot and dry; and there is watchfulness, nausea, and violent thirst.