The increasing Anguish and Pain they feel become inexpressible: they earnestly wish for Death; and some of them have even destroyed themselves, when they had the Means of effecting it. Sec. 192. It is with the Spittle, and the Spittle only, that this dreadful Poison unites itself. And here it may be observed, 1, That if the Wounds have been made through any of the Patient's Cloaths, they are less dangerous than those inflicted immediately on the naked Skin. 2, That Animals who abound in Wool, or have very thick Hair, are often preserved from the mortal Impression of the Poison; because in these various Circumstances, the Cloaths, the Hair, or the Wool have wiped, or even dried up, the Slaver of their Teeth. 3, The Bites inflicted by an infected Animal, very soon after he has bitten many others, are less dangerous than the former Bites, because their Slaver is lessened or exhausted. 4, If the Bite happens in the Face, or in the Neck, the Danger is greater, and the Operation of the Venom is quicker too; by Reason the Spittle of the Person so bit is sooner infected. 5, The higher the Degree of the Disease is advanced, the Bites become proportionably more dangerous. From what I have just mentioned here it may be discerned, why, of many who have been bitten by the same Sufferer, some have been infected with this dreadful Disease, and others not. Sec. 193. A great Number of Remedies have been highly cried up, as famous in the Cure of this Disease; and, in _Swisserland_ particularly, the Root of the Eglantine or wild Rose, gathered at some particular times, under the favorable Aspects of the Moon, and dried with some extraordinary Precautions. There is also the Powder of _Palmarius_ of calcined Egg Shells, that of the _Lichen terrestris_, or Ground Liverwort, with one third Part of Pepper, a Remedy long celebrated in _England_; Powder of Oyster-Shells; of Vervain; bathing in Salt Water; St. Hubert's Key, _&c. &c._ But the Death of a Multitude of those who have been bitten, notwithstanding their taking the greatest Part of all these boasted Antidotes; and the Certainty of no one's escaping, who had been attacked with the high raging Symptom, the _Hydrophobia_, have demonstrated the Inefficacy of them all, to all _Europe_. It is incontestable that to the Year 1730, not a single Patient escaped, in whom the Disease was indisputably manifest; and that every Medicine then employed against it was useless. When Medicines had been given before the great Symptom appeared, in some of those who took them, it afterwards appeared, in others not. The same different Events occurred also to others who were bitten, and who took not the least Medicine; so that upon the whole, before that Date, no Medicine seemed to be of any Consequence. Since that Time, we have had the Happiness to be informed of a certain Remedy, which is Mercury, joined to a few others.