Some of the Sick sent down from the Army were bad of Agues; but the greatest Number we had in Hospitals was composed of such as took it in Town; either from doing Duty on the Ramparts, or from lying in bad Quarters, or getting drunk and exposing themselves to Wet and Cold; and many Men of the invalid Companies who had come from _Embden_ brought with them old inveterate tertian and quartan Agues. Most of the recent Cases were easily cured by the Methods already mentioned; though they often continued longer, required a greater Quantity of the Bark to stop them, and a longer Continuance of its Use to make a Cure, than at other Places, which were more dry, and higher situated. The most obstinate of the recent Cases were the irregular Intermittents, which had regular Paroxysms, but where the Pulse was not settled in the Intervals; which we were obliged to treat as Remitting Fevers till the Paroxysms became quite distinct, and the Patient was cool and free from any Fever in the Intervals; after which they commonly yielded to the Bark. But many of those Agues which had continued for some Time, especially with those Invalids who came from _Embden_, or who had brought on frequent Relapses by their own Irregularities, were very obstinate. With many the Bark had no Effect; and its Use persisted in seeming rather to exasperate the Paroxysms, and to do Hurt. Nor had almost any Remedy we tried a better Effect. We gave the following Medicines to divers Patients; the saline Draughts and cooling Medicines; Infusions of Camomile Flowers and of other Bitters; Dr. _Morton_’s Powders of Camomile Flowers, Salt of Wormwood, and diaphoretic Antimony; Dr. _Mead_’s Powders of Camomile Flowers, Salt of Wormwood, Myrrh, and Alum; Alum and Nutmeg; large Doses of _sal ammoniac_; large Quantities of Spirits of Hartshorn; the antimonial Drops and Powders; to some we gave Emetics, both in the Intervals and immediately before the Fits. In some we tried to promote Sweats before the Approach of the Fits, by making them drink freely of warm Liquors while they kept in Bed, and took diaphoretic Medicines; and to others we applied Blisters.--But all did not put a Stop to some of those Agues. With some the Disorder continued till it broke down the Crasis of the Blood, and brought on a general Relaxation of the Fibres; and the Patients became cachectic, and fell into Dropsies, or were seized with Diarrhœas, of which they died. Some had Obstructions formed in the Liver or Spleen, or other _viscera_, and fell into the Jaundice and Dropsies, which carried them off.--In the Bodies, of several whom we opened, we found Indurations of the Liver and Spleen--in two of them Suppurations of the Liver--and in one, who had had the Ague at _Embden_, and had long complained of one of those Swellings towards the left Side of the _abdomen_, called the _Ague Cake_[86], the Spleen was so much enlarged as to weigh above four Pounds.