CASE IX.—Mr. Pacifico, a merchant, was attacked, and felt a pricking pain down the inside of the thick part of the thigh, near the sinews; he was obliged to go to bed. I visited him the next day, and was going to approach him, but he exclaimed, “Do not come near me, for although I know I have not the prevailing distemper, yet your friends, if you touch me, may persuade you otherwise, and that might alarm you; I shall, I hope, be well in a few days.” I took the hint of Don Pedro de Victoria, a Spanish gentleman, who was in the room, who offering me a sagar, I smoked it, and then departed; the next day the patient died. He was attended during his illness by the philanthropic Monsieur Soubremont, who did not stir from his bed-side till he expired; but after exposing himself in this manner, escaped the infection, which proceeded undoubtedly from his constantly having a pipe in his mouth. CASE X.—Two of the principal Jews of the town giving themselves up, and having no hope, were willing to employ the remainder of their lives in affording assistance to the dying and the dead, by washing the bodies and interring them; this business they performed during thirty or forty days, during all which time they were not attacked: when the plague had nearly subsided, and they began again to cherish hopes of surviving the calamity, they were both smitten, but after a few days illness recovered, and are now living. From this last case, as well as from many others similar, but too numerous here to recapitulate, it appears that the human constitution requires a certain miasma, to prepare it to receive the pestilential infection. _General Observation._—When the carbuncles or buboes appeared to have a blackish rim round their base, the case of that patient was desperate, and invariably fatal. Sometimes the whole body was covered with black spots like partridge-shot; such patients always fell victims to the disorder, and those who felt the blow internally, shewing no external disfiguration, did not survive more than a few hours. The plague, which appears necessary to carry off the overplus of encreasing population, visits this country about once in every twenty years: the last visitation was in 1799 and 1800, being more fatal than any ever before known.