2. This poison, whatever it may be, floats in the lower regions of the atmosphere, supported therein by the gaseous products of fermentation, and more especially by the ammonia now proved to exist everywhere in the atmosphere. It is the product, in fact, of the slow combustion perpetually going on in the air, the earth, the waters, wherever, in fact, animal or vegetable organisms are to be decomposed. We call it putrefaction; it is in truth a _ferment_, and the fermentable matter, that which gives rise to the ferment, is the immediate agent as well as the result (for it is the nature of all ferments to reproduce their process) of this fermentation, accumulated in the lower regions of the atmosphere. Increased to the dangerous point by men’s imprudence or ignorance, quickened by epidemic influences with whose nature we are of course wholly unacquainted, and absorbed by the living tissues, it excites that fermentation, that tendency to putrescence in the living blood to whose results medical men have given so many appellations. At times it is called ague; at times remittent fever; now it is small-pox; and now a fatal diphtherite. To the transit of _ferments_ through the air and to their inhalation by man, I ascribe the diseases usually called zymotic. In ancient primitive times, when physicians were rare,[63] and men did not interfere, a poison thus absorbed ran its course from incubation to specific fermentation, with all its results, in a given time, terminating in a crisis which might be calculated and determined; and which might prove fatal or at once remove the disease. A violent perspiration, a severe diarrhœa, a specific and contagious eruption on the surface of the body, proved and effected the elimination of the poison from the system. The ferment had done its work; it had altered the mass of the blood, and the products of the slow combustion (_putrescence_, rottenness, _fermentation_) were discharged by the secretions, according to circumstances peculiar to the constitution of the individual: as out of the same materials serpents elaborate poisons of very different powers and qualities, so the _ferment_, passing through various constitutions, gives rise to various results. It pervades the air and clings to it, nor can it be avoided but by a change of place of residence;[64] storms may, and no doubt do, affect it, but they frequently fail in dislodging the poison; intervening wide-spread oceans fail to interrupt its course;[65] and as regards the caprice exhibited in its attacks, we have only to reflect on the number of elements, vital, atmospheric, social, and chemical, involved in its full maturescence. Our doubts on all such matters originate probably in the coarse chemical theories and still coarser chemical experiments which prevailed about thirty years ago, and from their influence, from which men’s minds have not as yet escaped. The atmosphere was declared to contain a few wide-spread gaseous elements,