It is most likely that the sudden appearance of syphilis in nearly all parts of Europe at about the same time, which has been regarded as so extraordinary, can be explained by the clearer distinctions physicians began to make between symptoms of this disease and those of leprosy. Arrangements for the cure of lepers were very complete, and such syphilitic patients as responded kindly to the treatment thereby established themselves in a very different category of disease. The first writer to systematically consider venereal disease was Astruc, who was born in Languedoc in 1684 and died in 1766. He was the principal advocate of the view that syphilis had an American origin, in which view he was bitterly opposed by Sanchez, a Portuguese physician, who collected a large amount of evidence to the effect that its first ravages were observed in Italy. Summing up this whole matter, we may agree with Jourdan, who has examined all the opinions of these writers, and who, in his treatise published in 1826, concluded that all symptoms which had been hitherto connected with syphilis had been known and described from the remotest antiquity, but were not supposed to proceed{139} from a common source, and to be attached to the same cause, until after the close of the fifteenth century. THE INFLUENCE OF THE OCCULT SCIENCES ON THE MEDICINE OF THIS PERIOD. Most of the partisans of occult science were restless minds, such as are found in all ages, who chafed under the yoke of authority, and who practiced as well as deduced their lines of thought and conduct in accordance with their own ideas. Some of these men did not lack in sagacity, imagination, or audacity, but almost all of them lacked in consistency of idea and dignity of thought. Most of them lived isolated lives, apart from each other and from the rest of the world, and were, to a large extent, what we would now regard as "cranks." While they made a wide departure from accredited doctrine, they depended upon imagination rather than upon reason. This happened to be a period, however, when such men achieved great notoriety,--more so than the same class of individuals have done since their time.