[74] Weismann speaks disparagingly of Darwin’s theory as a “theory of _preformation_” (p. 316). “We must assume,” he adds by way of explanation, “that each single part of the body at each developmental stage is, from the first, represented in the germ-cell as distinct particles of matter, which will reproduce each part of the body at its appropriate stage as their turn for development arrives.” But must we not likewise “assume” exactly the same thing in the case of Weismann’s own theory? To me, at any rate, it appears that the description is quite as appropriate to germ-plasm as it is to gemmules. Nor can I see any distinction, even where he seeks to draw it more expressly, as for instance—“Every detail in the whole organism must be represented in the germ-plasm by its own special and peculiar arrangement of the groups of molecules, ... not indeed as the pre-formed germs of structure (the gemmules of pangenesis), but as variations in its molecular constitution.” [_Essays_, p. 194.] Again, on page 325 he gives a foot-note explaining the distinction by alluding to the controversy between the preformationists and epigenesists. But the theory of pangenesis does not suppose the future organism to exist in the egg-cell _as a miniature_: it supposes merely that every part of the future organism is represented in the egg-cell by corresponding material particles. And this, as far as I can understand, is exactly what the theory of germ-plasm supposes; only it calls the particles “molecules,” and seemingly attaches more importance to the matter of variations in their arrangement or “constitution,” whatever these vague expressions may be intended to signify. [75] ‘Philosophical Transactions of the Royal Society for the Year 1821,’ Part I. pp, 20-24. [76] Readers who may happen to be acquainted with De Vries’ important essay on heredity will perceive how well this suggestion fits in with his modification of Pangenesis.