DR. SIR JAMES GRANT, of Ottawa, has been led, by his studies of the alimentary canal in its function of discharging the secretions of the various glands, to a high appreciation of the importance of its operation in connection with the elaborate and complex nervous system associated with it. It is reasonable, he believes, to suppose that the activity of these nerves is injuriously affected by noxious influences long before any evidence of organic disease appears, and that, hence, want of care in the digestive process can not and does not fail "to bring about results of a most telling character in the very process of sanguinification." Believing that irregularities of the digestive process in the alimentary canal are more frequent than is generally supposed, he holds that "the internal sewage of the system" can not be too critically examined with a view of preventing the ill effect of toxic accumulations upon the nerve centers. "That the recently discovered neurones," he adds, "play an important part in the vitalizing of nerve energy is a reasonable deduction. A path is now open in which life, under ordinary circumstances, _may be prolonged_, provided no organic disease is present." The courses in biology in the University of Pennsylvania have been arranged with reference to the needs of students who desire instruction in the biological sciences for general culture, as a preparation for teaching or original investigation, or as a foundation for the professional course in medicine. They include in the courses in arts and sciences the electives, the biology-chemistry group, and the botany-zoölogy group, each set including several classes; the four-year course in biology, which appeals particularly to students who wish to become teachers or to take up special work as investigators in biology, and the two-years' course in biology, which is designed especially for those who desire some systematic training in natural science before taking up the study of medicine. Both of these courses are open to men and women alike. An ample equipment is provided for the biological department in the shape of spacious class rooms and laboratories, a botanic garden, an herbarium, a vivarium, zoölogical and auxiliary collections, a marine laboratory at Sea Isle, New Jersey, tables at Woods Holl, library facilities, two serial publications, and clubs and societies.