the foundation of degenerative tendencies which almost invariably predetermine the development of this affection in more or less remote succeeding generations. Nor do the children of such marriages necessarily or generally become insane, although they sometimes do; but, impressed as these are by the degenerative malnutritions and tensions and reactions of their parents, they tend to exhibit arrests and eccentricities of development, which in turn become intensified in the next, and again, in turn, in all the generations following, until the instability becomes so marked that explosion occurs. In passing, it may be said that the most frequent source of the initiatory tensions and reactions resulting from unphysiological marriage is undoubtedly found in abnormal cohabitation, and the unrest and unsatisfaction and exhaustion resulting therefrom. Such a condition of things begets in perfectly normal people an irritating, nagging, exhausting, persistent erethism, which in time involves the whole organism and deflects it from its norm. Two people enmeshed in such a bond always go to excesses and irregularities, either in abstinence or indulgence; or, if not this, then the whole matter becomes aversional, with straining antipathy, perverting practices, and ideational distrusts and loathings more and more predominating. No wonder that such people predetermine succeeding generations to abnormal sensitiveness, irregular growth, and erratic manifestations in both mental and physical spheres." (See New York Medical Journal for August 14, 1897; also Journal of Nervous and Mental Diseases, vol. xvii, page 669.)