Scribonius Largus had previously described, in nearly the same words, the collyrium,—“quod quidam εὐώδες vocant,” and its uses in recent cicatrices and granulations, etc. Both these authors give the same recipe for the composition of the _Evodes_,—viz. pompholyx, burnt copper, saffron, myrrh, hematites, opium, and other ingredients, rubbed down in Chian wine. Its agreeable odour was probably owing to a considerable quantity of spikenard being used in its composition.[445] Galen gives two other collyria, of a different composition, and for other affections, as known at his time under the same name of _Evodes_,—the one termed the “_Evodes_ of Zosimus,” the other the “diasmyrnon _Evodes_ of Syneros.”[446] 2. L. VALLATINI APALOCROCODES AD DIATHESIS.—_L. Vallatinus’ mild Crocodes for affections of the eyes._ The term diathesis in this inscription is used in a different sense from that in which we now employ the same word in modern medicine. At the present day we apply the term diathesis to designate the tendency or predisposition to some special disease, or class of diseases. In the times of the Roman physicians, it was often used as synonymous with disease itself; and in the Latin translations of the Greek texts of Galen, Aetius, etc., it is hence rendered usually by the general word “affectus,” “affectio,” etc. The first sentence in Paulus Ægineta’s chapter on Ophthalmic Diseases, affords an instance in point: “Quum dolores vehementiores in oculis fiunt, considera ex quanam affectione (διαθεσει) oculum dolere contingit.”[447] Thus, also, the _Evodes_ of Zosimus (to which I have before alluded) is entered by Galen as a remedy simply against “dolores et recentes affectus,” according to the Latin translation of Kühn,—“προς περιωδυνιας και προσφατους διαθεσεις,” according to the original Greek text. He uses diathesis, in fact, as a general term for eye-diseases. Thus, when speaking of diseases of the eye in general, he observes,—“Scripsi omnia quæ necesse est Medicum de oculorum affectibus (διαθεσεων) nosse.”[448] In its last syllable in the inscription on the seal, diathesIS stands instead of the Roman accusative diathesES, or the Greek accusative diathesEIS. This usage, however, is not without classical authority. The collyrium mentioned in the prescription (the _Crocodes_) derives its designation from its containing the crocus, or saffron, as one of its principal ingredients. In describing the therapeutic effects of the crocus, Dioscorides mentions, as its first special use, its efficacy in “fluxions of the eyes”—(oculorum fluxiones cohibet).[449]