Nor need I stop here to inquire into the much more difficult questions of the probable source of syphilis, and the exact date at which syphilis first burst forth in Europe. In relation to the object which I have at present in view, it matters not whether the malady sprang up spontaneously and endemically in Spain, Italy, or France, at the era in question; or was imported from Africa, as Grüner,[591] Infessura,[592] and others allege; or from Hispaniola, as Astruc,[593] Girtanner,[594] Weatherhead,[595] and various other authorities, have stoutly and not unsuccessfully maintained. Nor is it necessary for me to discuss whether it first showed itself in 1493, as Sanchez[596] and Hensler[597] consider that they have proved; or in 1492, as Fulgosi[598] asserts; or as early even as the month of October 1483, as Peter Pinctor,[599] in 1500, demonstrated astrologically, to his own complete satisfaction at least, that it ought to have done, inasmuch as that was—as he sagaciously convinced himself—the precise and exact date of the conjunction of Venus with Jupiter, Mars, and Mercury; and the conjunction of these or other stars in the heavens above, was—so he and many of the astrological physicians of his day believed—the undoubted origin of this new scourge on the earth below. In such a notice as the present, we may most safely, I believe, and that too without entertaining the question of the exact source or geographical origin of syphilis, start from the general proposition that the disease was in 1494 and 1495 first distinctly recognised in Italy, during the invasion of that country by the victorious army of Charles VIII. of France. The malady is usually allowed to have first broken out in a very marked degree at Naples, about the time that Charles took possession of that city, in the spring of 1495; or nearly two years after Columbus’ return from his first voyage to Hispaniola. Charles set out again for France in May 1495; and the malady seems to have been both diffused by his infected troops along the line of their northward march, and afterwards carried to their respective homes by his own French soldiers, as well as by his various Swiss, German, and Flemish auxiliaries.