It has long been thought that the iodides have some specific effect on the advancing arteriosclerosis, checking its spread, if not really aiding nature to a limited restoration of the diseased arteries. It is possible that the eulogies upon the iodides owe their origin to the successful treatment of syphilitic arteriosclerosis, in which condition these drugs have a specific action. However that may be, there is no doubt that the administration of sodium or potassium iodide is good therapeutics in cases of arteriosclerosis. Unfortunately many persons have such irritable stomachs that they can not take the iodides, even though they be diluted many times. They may be made less irritating by giving them with essence of pepsin. Unless the case is syphilitic, it is doubtful whether it is of value to increase the dose gradually until a dram or even more is taken three times daily after meals. Usually a maximum dose of ten grains seems to be quite sufficient. This may be taken three times a day, well diluted, for three months. There follows a month's rest, then the treatment is resumed for another period of three months, and so on. Either sodium or potassium iodide in saturated solution may be given. The sodium salt is possibly less irritating, and contains more free iodine than the potassium salt, although the latter is more generally used. The strontium iodide may also be used. One sees a patient now and then who can not take the iodides, however they may be combined. For such patients one may obtain good results with iodopin, sajodin, or other of the preparations put up by reputable firms. Personally I have never yet seen a patient who could not take the ordinary iodides in some form or other, and I am opposed to ready made drugging. The action of the iodides is to lower the blood pressure, and they are of greatest value when the blood pressure is high, and when headache and precordial pain are present. When the case is moderately advanced, very mild doses, gr. 1/2, morning and evening, of the thyroid extract may be given. It is generally believed that the internal secretion of the thyroid and the adrenal are antagonistic. That the thyroid secretion lowers blood pressure in certain forms of hypertension is certain, possibly on account of its iodine content. Some combinations of iodine and thyroid such as the iodothyroidin have been used and have had some measure of success attributed to them.