One of the results of arteriosclerosis of the coronary arteries, angina pectoris, demands prompt treatment. In the acute attack, the chief object is to relieve the spasm and pain. Pearls of amyl nitrite should be inhaled, and morphine sulphate with atropine sulphate given hypodermatically at the very earliest moment. It is senseless to withhold morphine. The only possible reason for withholding it would be uncertainty as to the diagnosis. It is probably better to err on the safe side, and should the case prove to be one of pseudo angina, in the next attack sterile water can be given instead of the morphine and atropine. When a patient is seen in the condition of broken compensation with the much dilated heart, anasarca, dyspnea and suppression of urine, there is no better practice than venesection. Especially is this valuable when the tension is still fairly high and the individual is robust. Following the abstraction of six to eight ounces of blood (300-500 c.c.)[21] the whole picture changes, so that a man who a short while before was apparently at death's door, notices his surroundings and takes an interest again in life. This should be followed up with thorough purgation, and cardiac stimulants should be ordered. In such cases digitalis is useful, but its action is never so striking as in cases of this general character due to uncompensated valvular disease. It must be remembered that in arteriosclerosis the changes in the myocardium must be of a considerable grade for the heart to give away. Therefore, digitalis can not be expected to act on a diseased muscle as it acts on a comparatively healthy muscle. It is only in such cases of broken compensation that digitalis should ever be used. [21] I have taken as much as 1700 c.c. from a large man. He recovered and went back to work. Digitalis is not a general vasoconstrictor as used to be taught. Its action on the kidney is actually a vasodilator one. And in its action on the heart the digitonin dilates the coronary arteries, according to Macht, while the digitoxin acts on the heart muscle. Overdosing with digitalis has produced partial heart block in many cases. It is absolutely contraindicated in Stokes-Adams syndrome. There are, however, some cases, especially those with transudations, when digitalis may be carefully tried even though high tension be present. It is sometimes of advantage to combine digitalis with the nitrites although they are said to be physiologically incompatible. Still another drug, that is of great value in conditions such as have been described, is diuretin. This may be given in capsule or tablets, grs. x. three times daily. There is only one caution to express in the use of this drug. It should not be given when the kidneys are the seat of chronic inflammatory changes; in fact, actual harm may be done by administering the drug under such conditions.