Arteriosclerosis and Hypertension, with Chapters on Blood Pressure: 3rd Edition.Warfield, Louis M. (Louis Marshall)
Science
Arteriosclerosis and Hypertension, with Chapters on Blood Pressure: 3rd Edition.
Warfield, Louis M. (Louis Marshall)
Arteries -- Diseases; Blood pressure
Group B. This one might designate as the hereditary type, although there
is not always a history in the antecedent. This group includes the
robust, florid, exuberantly healthy people. They often are heard to
boast that they have never had a doctor in their lives. They are usually
thick-set or very large, fleshy people. The pressure picture is
exceedingly high. The pulse pressure is moderately increased. The
arteries are rather large, fibrous, and often quite tortuous, although
this is not always the case. Some persons have hard, small, fibrous
arteries. There is no puffiness beneath the eyes, no polyuria, and no
nycturia as a rule. The urine is of normal amount, color, and specific
gravity. Albumin is only rarely found and then in traces, but careful
search of a centrifuged specimen invariably reveals a few hyaline
casts. The phthalein excretion is normal or only slightly reduced. The
kidneys excrete salt and nitrogen normally. It is in this group that
apoplexy is found most frequently. The rupture of the vessel occurs when
the victim is in perfect health, often without any warning. Occasionally
when such a case recovers sufficiently to be around, cardiac
decompensation sets in later and he dies then of the cardiac
complications.
Pathologically the hearts of such persons are found to have the most
enormous hypertrophy of the wall of the left ventricle. The cavity is
somewhat enlarged, as is always the case when the pulse-pressure is
increased, but the size of the cavity is not the striking feature. The
aorta is fibrous, thick walled, and the arch is slightly dilated. There
are patches of arteriosclerosis. One such case seen only at autopsy had
a rupture of the aorta just above the sinus of Valsalva and died of
hemopericardium. The kidneys are of normal size, dark red, firm, the
capsule strips readily, the surface is smooth or finely granular, the
cortex is not decreased. The pyramids are congested and red streaks
extend into the cortex. Microscopically the capsules of the glomeruli
are a trifle thickened; a few show hyaline changes. There is rather
diffuse, mild, round-cell infiltration between the tubules. The tubular
epithelium shows little or no demonstrable changes. The arterioles are
generally the seat of a moderate thickening of the intima and media, but
it is not usual to find obliterating endarteritis. There is evidently a
diffuse fibrous change which has not affected either the tubules or
glomeruli to any great extent.
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