M.--S.--From dram j. to ounce ss. every half-hour, hour or two hours, according to the urgency of the symptoms and the stage of the disease. As soon as relief is obtained, it should be given in minimum doses and less frequently. This is admirably adapted to the cold stage, and will give prompt relief in a great majority of cases. In the premonitory stage, it can be administered to good advantage in small and less frequent doses. In some instances, an additional astringent may be necessary. The deceptive and painless diarrhoea should receive prompt attention, and be regarded and treated as the incipient form of the disease. According to the best authorities, the diarrhoea commences with the first chemical change or alteration of the blood, and proceeds gradually, in most cases, for some hours, and even in some instances, though rarely, for days. It is not sufficient to check the diarrhoea merely; the cause must be removed, which is essentially of miasmatic origin. When the cholera is prevailing, and the diarrhoea is essentially choleraic, or the result of a depressing miasmatic influence, it should be treated with chloroform, aided, if required, by appropriate astringents. In the fully developed stage, and even in the stage of collapse, perhaps no combination is better adapted to meet promptly all the necessities and wants of the system, and suspend the action of the cholera-poison, than the one named above. It is a simple, prompt and diffusive stimulant, approximating the principle indicated. This peculiar remedy is essentially required, and should be continued through all the stages of the disease till relief be obtained, varying its administration according to the urgency of the symptoms. When the stomach is too irritable to retain medicine, it should be given by the bowel. Take of the above mixture, one-half ounce, of the tincture of prickly-ash berries one-half ounce, of the tincture of opium ten drops, of warm water one ounce and a half--mix and inject. This may be repeated after every evacuation three or four times, unless relief be obtained earlier. Thus, it should be administered perseveringly by stomach and by bowel, aided by due employment of all necessary external means for furnishing warmth and giving relief. Opium, however, should be omitted after two or three injections. Its continued use to check the movement of the bowels is decidedly injurious. The vomiting and irritability of the stomach may often be allayed by a strong decoction of spearmint and horse-peppermint (monarda punctata), equal parts, alternated with camphor water in small repeated doses every five minutes. This will often succeed when all other means fail.