It is utterly impossible for me to support the Buffalo nomination. I have no confidence in Mr. Van Buren, not the slightest. I would much rather trust General Taylor than Mr. Van Buren even on this very question of slavery, for I believe that General Taylor is an honest man and I am sure he is not so much committed on the wrong side, as I know Mr. Van Buren to have been for fifteen years. I cannot concur even with my best friends in giving the lead in a great question to a notorious opponent to the cause. Besides; there are other great interests of the country in which you and I hold Mr. Van Buren to be essentially wrong, and it seems to me that in consenting to form a party under him Whigs must consent to bottom their party on one idea only, and also to adopt as the representative of that idea a head chosen on a strange emergency from among its steadiest opposers. It gives me pain to differ from Whig friends whom I know to be as much attached to universal liberty as I am, and they cannot be more so. I am grieved particularly to be obliged to differ in anything from yourself and your excellent father, for both of whom I have cherished such long and affectionate regards. But I cannot see it to be my duty to join in a secession from the Whig Party for the purpose of putting Mr. Van Buren at the head of the Government. I pray you to assure yourself, my dear Sir, of my continued esteem and attachment, and remember me kindly and cordially to your father. Yours, etc., DANIEL WEBSTER Honorable E. Rockwood Hoar.