_Experiment No. 3._--July 13, 1906, a sheep weighing 19.5 kilos was fed with 640 c.c. of fluid, representing the extract of 2,000 grams of _Aragallus lamberti_. The temperature at the time of feeding, 1.10 p. m., was 105.3°F. At 1.49 p.m. the sheep could be easily turned on its back. At 2.23 p.m. the temperature was 103.6°F. At 3.42 p.m. the temperature was 103.5°F. At 4.20 p.m. the respiration was fairly rapid. On July 14, at 11.15 a.m., the temperature was 103.6°F. The sheep would run about but could easily be turned over. It had not eaten, but there was diarrhea present. July 15, at 3.30 p.m., the temperature was 104°F. The animal had eaten. On July 17 the temperature was 104°F. and the animal weighed 18.8 kilos. On the 27th it weighed 17.2 kilos; on August 29, 20.8 kilos. _Experiment No. 4._--A lamb weighing 19 kilos was fed August 21, 1906, with 740 c.c., representing the aqueous extract of 2,500 grams of the fresh _Astragalus mollissimus_, shipped to Washington in September, 1905. This animal ate at night, but the following day was dull. When seen on August 27 there was diarrhea present and the animal was still dull. On the 28th the animal died, weighing 16.7 kilos. There was no autopsy on account of decomposition. _Experiment No. 5._--A lamb weighing 15.6 kilos was fed on September 4, 1906, with an aqueous extract representing 3,500 grams of the dried _Aragallus lamberti_, 1,000 c.c. of water being used. The temperature at the time of feeding was 104.3°F. At 2.48 p.m. the animal on rising to its feet developed a slight tremor of the fore legs and showed marked disinclination to stand on its feet. The temperature was 104°F. The animal died at 4.25 p.m. The post-mortem was negative, save for some reddening of the second stomach.[157] These feeding experiments in sheep can not be considered quantitative, because, as is shown later, aqueous extracts of dried plants are often inactive, yet poisonous principles may be obtained from the plants by treatment with digestive fluids. Extracts of dried loco plants vary much in their toxicity; with some the writer was unable to kill rabbits, even when an extract of 300 grams of the dried plant was used. It is interesting to note that when the field station was established at Hugo, Colo., in 1905, almost all the aqueous extracts of dried specimens sent to Washington would produce the acute symptoms of poisoning in rabbits, but during the third season of its existence many of the samples sent from the same area were much less active, if not inactive. * * * * * FOOTNOTES: [157] There was a slight odor of chloroform noticed on opening the stomach, so that perhaps the imperfect removal of the chloroform due to a hurried evaporation of the extract should be taken into consideration in this case. =LABORATORY EXPERIMENTS--CHEMICAL.=