Barium: A Cause of the Loco-Weed DiseaseCrawford, Albert C. (Albert Cornelius)
Science
Barium: A Cause of the Loco-Weed Disease
Crawford, Albert C. (Albert Cornelius)
Astragalus earlei; Barium
On June 13 the animal began to eat, and 1,700 c.c. of fluid,
representing 5,500 grams of the fresh _Aragallus lamberti_, were fed.
The temperature at 12.30 p.m. was 103°F. On June 14 the temperature
was 103.4°F., the animal weighed 28.3 kilos, and refused food. On June
16 the weight was 28.3 kilos; the temperature at 2 p.m. was 103.5°F.
There was no diarrhea.
On June 19 the aqueous extract of 1,000 grams of the dried _Astragalus
mollissimus_ was fed with 420 c.c. of water. The temperature was 102.6°
F. On June 20 the temperature was 102.9°F. at 10.45 a.m.
On June 21 500 c.c., representing the aqueous extract of 1,000 grams of
the dried _Astragalus mollissimus_, were again fed. The animal now
weighed 26.9 kilos. On June 26 the animal weighed 26 kilos, and its gait
was very uncertain. The temperature was 104.2°F. It was fed 300 c.c.
of fluid, representing the extract of 400 grams of the dried _Astragalus
mollissimus_. On June 29 the animal weighed 26.8 kilos and the
temperature was 102.8°F. It was fed the extract of 1,000 grams of dried
_Astragalus mollissimus_ in 500 c.c. of water. On June 30, at 10.45 a.
m., the temperature was 104.2°F. The animal was very dull and died at
night.
At autopsy the intestines and stomach merely appeared pale. There were
no worms, and the lungs and other organs appeared normal.
_Experiment No. 2._--A lamb weighing 15.4 kilos was fed on July 6, at
1.10 p.m., with 640 c.c. of fluid, representing the extract of 2,000
grams of _Astragalus mollissimus_. At 1.17 p.m. the animal could be
turned on its back, and it regained its feet with difficulty. At 1.24 p.
m. it urinated and had a stool. The lamb died during the night.
The autopsy the following morning showed the heart filled with clots;
lungs normal save for hypostatic congestion. The cerebral and dural
vessels were dilated. About 1-1/2 teaspoonfuls of bloody serum were
found at the base of the brain. There was none in the lateral
ventricles, and no clots. The kidneys exhibited no marked congestion.
There was no fluid found in the peritoneal or the pleural or pericardial
cavities. The first stomach, however, contained small hemorrhagic spots,
and the second was black. There were small hemorrhages in the
intestines.
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