As to specific cases of the effects of this disease on descendants the literature of the subject is crowded full. While it is needless to conduct the reader through a chamber of horrors by reviewing clinical cases, it is desirable to point out in a general way some of the effects. Doctor George H. Kirby, director of Clinical Psychiatry, Manhattan State Hospital, says: "We find that when either the father or the mother suffers from paresis that many other members of the family may be infected with syphilis, and furthermore, we find that a large number of children in these families are feeble-minded, nervous, or in other ways abnormal. Doctor Plant examined a group of 100 children, the offspring of cases of paresis, and found that 45 per cent. were plainly damaged mentally or physically, or in both fields; the blood test showed that one-third of these 100 children had the syphilitic poison in their systems. "Another investigator found in a group of 139 children, the descendants of parents who had syphilitic nervous disease, that over 25 per cent. were definitely feeble-minded or affected with some serious nervous disorders. "Other studies indicate that there exists a close relation between syphilis and many of the hitherto unexplained cases of feeble-mindedness, including idiocy, imbecility, infantile paralysis, and some forms of epilepsy. While the question is not yet settled, it appears that syphilis is the real cause of many of these cases of mental defect in children." Still other investigators give details of physical afflictions and distortions, of suppressed development, of inordinate percentages of stillbirths--perhaps the most merciful lot for the little victims--but sufficient has been said to indicate the full horror of the situation. Goddard,[7] although not minimizing the terrible nature of the disease, finds little evidence in his studies that syphilis in parents is a specific cause of feeble-mindedness.