Even in individual states with exceptionally large university populations we still find these outnumbered by those of the insane. Thus in Wisconsin by 1914 the state university had attained a population of about 4,700 students resident at the university during the regular school year, and of approximately 6,000 attending during some part of the year, but the number of insane under restraint in public institutions in the state June 20, 1912, was 6,851, with an additional 1,284 on parole. This does not include the insane in various private sanatoria, and moreover a considerable greater number of patients had been treated in these public institutions than were resident there June twentieth. To make such comparisons complete one should, of course, know the average length of residence of students in college, and of insane patients in institutions. No accurate data on this point are at hand. The average period of residence in hospitals for the acutely insane is doubtless considerably shorter than the average period of attendance of students in college, while on the other hand the average period of residence of inmates in asylums for chronic insane is probably considerably longer. For example, the Wisconsin State Hospital for the Insane reports a total of 1,224 patients under treatment, but an average population at any one time of only 622 during the year 1911, and the Northern Hospital for the Insane, a total of 1,194, with a daily average of 613 during the same period. The combined thirty-four county asylums in Wisconsin, for chronic insane, had a total population of 5,384 during the year 1911, with a loss of 517, or approximately 10 per cent. During 1912 the figures for these same institutions run 5,758 and 742 respectively, or a loss of over 12.5 per cent. The conditions in other states are probably much the same. In other representative states we find the number of insane in public institutions as follows: California, 7,909; Michigan, 7,703; Minnesota, 5,329; Pennsylvania, 16,992. Epileptics are estimated by alienists to be about equal in number to the insane, feeble-minded to be more numerous. The estimate that in the United States there are 300,000 feeble-minded is probably a minimal figure. =Imperfect Adjustments of the Brain Mechanism Often Inheritable.--=The outside layer or "cortex" of the brain is the region in which the more complicated adjustments occur, especially such as pertain to human behavior, and inasmuch as this portion of the brain is extremely complex and delicate in its mechanism, it is peculiarly liable to derangements which, even when slight, may have far-reaching effects.