He was happily married to one Agness Campbel, daughter to David Campbel of Sheldon in the shire of Ayr, a remote branch of the family of Loudon. August 1645, his family affairs were both easy and comfortable. His wife was a gentlewoman endued with all the qualities that could render her a blessing to her husband, joined to handsome and comely features, good sense and good breeding sweetened by a modest cheerfulness of temper, and, what was most comfortable to Mr. Guthrie, she was sincerely pious, so that they lived a little more than twenty years in the most complete friendship, and with a constant mutual satisfaction founded on the noblest principles; one faith, one hope, one baptism, and a sovereign love to Jesus Christ, which zealously inspired them both. By her he had six children; two of whom only out-lived himself; both of them daughters, who endeavoured to follow the example of their excellent parents; one of them was married to Miller of Glenlee, a gentleman in the shire of Ayr, and the other to Mr. Peter Warner _anno_ 1681.; after the revolution, Mr. Warner was settled at Irvine. He had two children, William of Ardrie in Ayr-shire, and Margaret Warner, married to Mr. Wodrow minister at Eastwood, who wrote the history of the sufferings of the church of Scotland betwixt the years 1660 and 1688, inclusive.--But to return. When Mr. Guthrie was but young and new married, he was appointed by the general assembly to attend the army. When he was preparing for his departure, a violent fit of the gravel (unto which he was often subject) reduced him to the greatest extremity of pain and danger; which made his religious spouse understand and improve the divine chastisement; she then saw how easily God could put an end to his life, which she was too apprehensive about, and brought herself to a resolution never to oppose her inclination to his entering upon any employment, whereby he might honour his Maker, though never so much hazard should attend it. While he was with the army, upon the defeat of a party he was then with, he was preserved in a very extraordinary manner; which made him ever after retain a greater sense of the divine goodness; and after his return to his parish, was animated to a more vigorous diligence in the work of the ministry, and propagating the kingdom of the Son of God, both among his people and all round about him; his public preaching, especially at the administration of the Lord's Supper, and his private conversation conspiring together for these noble purposes.