After this Mr. Guthrie continued in Fenwick until the year 1665. The brother, to whom his paternal estate was made over, dying in summer, Mr. Guthrie's presence at home was the more necessary, for ordering of his private affairs; which made him and his wife make a journey to Angus about the same time. He had not been long in that country until he was seized with a complication of distempers; the gravel, with which he had been formerly troubled; the gout; a violent heart-burning; and an ulcer in his kidneys: All which attacked him with great fury. And being thus tormented with violent pain, his friends were sometimes obliged to hold down his head and up his feet; and yet he would say, The Lord hath been kind to him, for all the ills he had done; and at the same time said, "Though I should die mad, yet I know I shall die in the Lord.--Blessed are the dead that die in the Lord at all times, but more especially when a flood of errors, snares and judgments are beginning, or coming on a nation, church or people." In the midst of all his heavy affliction he still adored the measures of divine providence, though at the same time he longed for his dissolution, and expressed the satisfaction and joy with which he would make the grave his dwelling-place, when God should think fit to give him rest there.----His compassionate Master did at last indulge the pious breathing of his soul; for, after eight or ten days illness, he was gathered to his fathers, in the house of his brother in-law, Mr. Lewis Skinnier of Brechin, upon Wednesday forenoon, October 10th, 1665, (in the 45th year of his age), and was buried in the church of Brechin, under Pitfrothy's desk. During his sickness he was visited by the bishop of Brechin, and several episcopal ministers and relations, who all had a high value for him, notwithstanding he exprest his sorrow (with great freedom) for their compliance with the corrupted establishment in ecclesiastical affairs. He died in the full assurance of faith as to his own interest in God's covenant, and under the pleasing hopes that God would return in glory to the church of Scotland. Mr. John Livingston, in his memorable characteristics, says, "Mr. William Guthrie, minister at Fenwick, was a man of a most ready wit, fruitful invention, and apposite comparisons, qualified both to awaken and pacify conscience, straight and zealous for the cause of Christ, and a great light in the west of Scotland."--And elsewhere says, "Mr. Guthrie, in his doctrine, was as full and free as any man in Scotland had ever been; which, together with the excellency of his preaching gift, did so recommend him to the affection of his people, that they turned the corn-field of his glebe into a little town, every one building a house for his family on it that they might live under the drop of his ministry."