C. S., aged twenty-two, a strong and healthy young man, a student of surgery, on commencing the inhalation, coughed, and there was a flow of saliva and of tears. In three and a half minutes the skin appeared insensible to pain. Consciousness remained perfect and undisturbed. The skin was warm; the eyes were open; the hearing as usual; the speech, however, was difficult. This state continued eighteen minutes, during which, at _his request_, two teeth with large fangs were extracted. He held himself perfectly still. He said, afterwards, that _he felt the application of the instrument, but was sensible of no pain_, during the extraction of the teeth. W. S., aged nineteen, a strong and healthy young man, a law-student, after inhaling the ether-vapour a minute, began to move his arms about, struck his knees, stamped with his feet, laughed. In three minutes the laughter and excitement had increased. The eyes rolled, he sprang up, talked volubly; the pulse was strong and frequent. In seven minutes he breathed deeply, the eyelids closed, the pulse sank. In eight minutes he began to snore, but heard when called to. In nine minutes the eyes were suffused; the optic axes were directed upwards and outwards. At the end of twelve minutes a tooth was extracted, when he uttered an exclamation and laughed. On his return to himself, he said that he had _felt the laceration, or tear, but had experienced no pain_. He thought he had been at a carousal. If I add to these sketches that the patient sometimes becomes pale, sometimes flushed,--that the pupils of the eyes are generally dilated and fixed, sometimes natural and fixed, sometimes contracted,--that violent excitement sometimes manifests itself attended with the persistence or even exaltation of the ordinary sensibility,--that sometimes hysteric fits are brought on; sometimes a state resembling common intoxication,--you will have had the means of forming a sufficiently exact and comprehensive idea of the features of etherisation.