The trees from which the bark is used all belong to the genus _Cinchona_, named for the first distinguished patient to benefit by it, and belong to the _Rubiaceæ_ or madder family. There are at least four or five different species. For many years Peru and near-by states were the only source of the bark, and the English became convinced that the great trade in the drug would exterminate the tree, so in 1880 they introduced the plant into India. These cinchona plantations now provide most of the world’s demand, and some idea of what that means may be gleaned from the fact that in Ceylon alone over fifteen million pounds of the drug are produced annually. In India itself the plantations are largely government owned and quinine is sold in the post offices at a very low rate. In cinchona plantations strips of the bark are removed, and after a proper period of healing, the process is repeated. It takes about eight years before it is safe to begin cutting the bark. ACONITE Most doctors use aconite for various purposes and it is mentioned here chiefly as illustrating a common characteristic of many medicinal plants. The whole plant is deadly poisonous, and in the root there appears to be a concentration of this poisonous substance, which makes the plant one of the most dangerous known. All of the drug aconite is derived from _Aconitum Napellus_, a monkshood, belonging to the buttercup family. It is a perennial herb with beautiful spikes of purple-blue flowers, not unlike a larkspur, and is a native of temperate regions of the Old World. A related Indian species has been used for probably thousands of years by the natives. They poison their arrows with it and so deadly is the drug that a tiger pricked by such an arrow will die within a few minutes. It is conceded to be the most powerful poison in India. Numerous accidents have resulted in Europe from careless collectors of the roots of horseradish, who sometimes get aconite roots mixed with that condiment, usually with fatal results. So many other plants are violently poisonous, and yet yield the most valuable drugs, that the greatest care has to be used in their collection and preparation. The habit of many children of eating wayside berries should be discouraged, as some of our most innocent-looking roadside plants are actually deadly if their fruits or foliage are eaten. Fortunately only a very few plants are poisonous to the touch, notably poison ivy and poison sumac, and some of their relatives. OPIUM AND MORPHINE