In considering the discovery of etherization we ought to eliminate all evidence of an _ex parte_ character, unless it is supported circumstantially; but there is no reason why we should disbelieve Mrs. Morton's statement that her husband made experiments with sulphuric ether; that his clothes smelt of it; and that he tried to persuade laboring-men to allow him to experiment upon them with it. As Dr. J. Collins Warren says: "Anaesthesia had been the dream of many surgeons and scientists, but it had been classed with aerial navigation and other improbable inventions." [Footnote: Anaesthesia in Surgery, 15.] As long ago as 1818 Faraday had discovered the chief properties of ether, with the exception of its effect in deadening sensibility. In 1836 Dr. Morrill Wyman and Dr. Samuel Parkman had experimented with it on themselves at the Massachusetts Hospital, but without taking a sufficient quantity to produce unconsciousness. It was actually employed in 1842 by Dr. Crawford W. Long, at the University of Pennsylvania, in some minor cases of surgery, but he would seem to have lost confidence in his method and afterwards abandoned it. In December, 1844, Horace Wells, a dentist of Hartford, had a tooth extracted by his own request while under the influence of nitrous oxide; and the following month he came to Boston, and having made his discovery known, an operation at the hospital was undertaken with his assistance, but the patient screamed, and it proved a failure so far as anaesthesia was concerned. From these facts we readily draw the following conclusions: That the discovery of painless surgery was essentially a practical affair for which only a slight knowledge of chemistry was required; that it was not a discovery made at hap-hazard, but one that necessitated a skilful hand and a clear understanding of the subject; and that the supposition which has sometimes been advanced that Doctor Morton was necessarily indebted to Doctor Jackson for a knowledge of the hypnotic effect of ether is wholly gratuitous. We will now quote directly from Doctor Warren's lecture on "The Influence of Anaesthesia on the Surgery of the Nineteenth Century," delivered before the American Surgical Association in 1897: "Morton having acquainted himself by conversation with Mr. Metcalf and Mr. Burnett, both leading druggists, as to purity and qualities of ether, and having also conversed with Mr. Wightman, a philosophical instrument- maker, and with Doctor Jackson as to inhaling apparatus, proceeded to experiment upon himself. After inhaling the purer quality of ether from a handkerchief he awoke to find that he had been insensible for seven or eight minutes.