Of the causes of this disease, Youatt, who is almost the only authority we have upon this subject, says: "It seems occasionally to be epidemic; for several instances of it occur, of the same character, and in the same district. M. Cruzel gives an illustration of this in his description of the disease that destroyed so many cattle, in the years 1826 to 1827, in the Department _de la Nievre_. Out of two hundred and eighteen cattle belonging to three farmers, one hundred and thirteen were attacked by this disease, and eighty-three of them died. One farmer in a neighboring district had nineteen head of cattle, all of which sickened, but only three were lost. These were unusually hot summers. The upland pasture was burnt up, or what remained of it was rendered unusually stimulating; and the acrid plants of the marshes and low grounds acquired additional deleterious agency. "When isolated cases occur, they may generally be attributed to mismanagement. Exposure to cold, or the drinking of cold water when overheated with work; too hard work in sultry weather; the use of water stagnant, impure, or containing any considerable quantity of metallic salts; the sudden revulsion of some cutaneous eruption; the crowding of animals into a confined place; too luxuriant and stimulating food generally; and the mildewed and unwholesome food on which cattle are too often kept, are fruitful sources of this complaint." _Treatment._--In the early stage of the disease, give an active purge, and follow it with ten drops of Fleming's tincture of aconite, four times daily, for two days; then give drachm doses of the extract of belladonna; give no food for twenty-four or forty-eight hours, according to circumstances. Bleeding, if done early, is often beneficial. Counter-irritants to the belly are also recommended; the best are mustard, hartshorn, and water, mixed together--or tincture of cantharides, with one drachm of croton-oil added to every ounce. EPIZOOeTICS. Diseases of this class have the same relation to the inferior animals that epidemic diseases have to man. Of course, they assume a very pestilential character. Scarcely a year passes away without diseases of this nature making their appearance in some parts of the world. They occur at all seasons of the year, but more generally prevail in the spring and fall. The period of their duration varies from months to years. They are, at times, mild in their attacks, and yield readily to proper treatment; at other times, they become painful pestilences, destroying every thing in their course. The causes are generally sought for in some peculiar condition of the atmosphere. The use of the milk and flesh of diseased cattle has frequently been productive of malignant diseases in the human family. Silius Italicus describes a fearful epizooetic, which first attacked the dog, then the feathered biped, then horses, and cattle, and, last of all, the human being.