"The leading symptoms in all were the same, with minor differences; and so, too, was the appearance after death, on examination. "Of all that were taken sick (sixteen) but two recovered; and they were among those we did the least for, after we had become discouraged about trying to cure them. In all the last cases we made no effort at all, but to keep them as comfortable as we could. In one case, the acute character of the disease changed to chronic, and the animal lived six or eight weeks, until the whole texture of the lungs had become destroyed. She had become much emaciated, and finally died with the ordinary consumption. "At the time the first case appeared, I had a herd of thirty-one animals, all valuable Ayrshires, in fine condition and healthy. In all the first cases, I had a veterinary surgeon of considerable celebrity and experience, and every ordinary approved method of treatment was resorted to and persevered in. The last cases--as before intimated--we only strove to make comfortable. "After I had paid the third or fourth forfeit, I began to awake up to the idea that the disease was, in a high degree, contagious, whether I would have it so or not; and that my future security was in prevention, and not in remedy. I therefore separated all the remaining animals; in no instance having more than two together, and generally but one in a place. "All were removed from the infected stalls, and put into quarantine. Isolated cases continued to occur after this for some weeks, but the spread of the disease was stayed; nor did a single case occur after this, which we did not think we traced directly to previous contact. "It is impossible to account for the first case of which I have spoken. But, as the cow in that case was put into a sale-stable in New York while waiting for the boat,--though there were no cattle then present,--yet I have supposed it not unlikely that diseased animals had been there, and had left the seeds of the disease. "But, account for this case as we may,--and I have no doubt it is sometimes spontaneous,--I feel convinced it is very highly contagious; and that the only safety to a herd into which it has been introduced, is in complete isolation,--and in this I feel as convinced that there is safety. My cattle were not suffered to return to the barnyard or to any part of the cattle-barns, except as invalids were sent to 'the hospital' to die, until late the next fall, _i.e._, the fall of 1854. In the mean time, the hay and straw had all been removed; the stables, stalls, cribs and all thoroughly scrubbed with ashes and water, fumigated, and white washed with quicklime. I have had no case since, and am persuaded I should have avoided most of those I had before, if I had reasonably admitted the evidence of my senses in the second and third cases. E. P. PRENTICE. MOUNT HOPE, June 14th, 1860."