This combination of the poetical with the legal mind was parallelled by other combinations in such masters of "Responses" as the Sheshet and Duran families in Algiers in the fourteenth and fifteenth centuries. In these men depth of learning was associated with width of culture. Others, such as Moses and Judah Minz, Jacob Weil, and Israel Isserlein, whose influence was paramount in Germany in the fifteenth century, were less cultivated, but their learning was associated with a geniality and sense of humor that make their "Responses" very human and very entertaining. There is the same homely, affectionate air in the collection of _Minhagim_, or Customs, known as the _Maharil_, which belongs to the same period. On the other hand, David Abi Zimra, Rabbi of Cairo in the sixteenth century, was as independent as he was learned. It was he, for instance, who abolished the old custom of dating Hebrew documents from the Seleucid era (311 B.C.E.). And, to pass beyond the time of Karo, the writers of "Responses" include the gifted Jair Chayim Bacharach (seventeenth century), a critic as well as a legalist; Chacham Zevi and Jacob Emden in Amsterdam, and Ezekiel Landau in Prague, the former two of whom opposed the Messianic claims of Sabbatai Zevi, and the last of whom was an antagonist to the Germanizing tendency of Moses Mendelssohn. Joseph Karo himself was a man of many parts. He was born in Spain in 1488, and died in Safed, the nest of mysticism, in 1575. Master of the Talmudic writings of his predecessors from his youth, Karo devoted thirty-two years to the preparation of an exhaustive commentary on the "Four Rows" of Jacob Asheri. This occupied him from 1522 to 1554. Karo was an enthusiast as well as a student, and the emotional side of the Kabbala had much fascination for him. He believed that he had a familiar, or _Maggid_, the personification of the Mishnah, who appeared to him in dreams, and held communion with him. He found a congenial home in Safed, where the mystics had their head-quarters in the sixteenth century. Karo's companion on his journey to Safed was Solomon Alkabets, author of the famous Sabbath hymn "Come, my Friend" (_Lecha Dodi_), with the refrain: Come forth, my friend, the Bride to meet, Come, O my friend, the Sabbath greet!