The function of respiration is to supply oxygen to and remove carbon dioxide from the blood as it passes through the lungs. This interchange of gases takes place in the alveoli, a myriad of thin-walled air sacs at the end of the respiratory tract where the air is separated by a very thin membrane through which the gases readily pass. The volume and rate, or in other words, the minute-volume, of respiration is automatically controlled by the nerve centers in such a way that a sufficient amount of air is supplied to the lungs to maintain by means of this interchange a uniform percentage of its various constituents as it leaves the lungs. It will be readily seen therefore, that anything which causes a change in the composition of the air presented to the blood in the alveoli will bring about abnormal conditions of respiration. Inasmuch as the gaseous interchange between the lungs and the blood takes place only in the terminal air sacs it follows that, at the end of each respiration, the rest of the respiratory tract is filled with air low in oxygen and high in carbon dioxide, which on inspiration is drawn back into the lungs, diluting the fresh air. The volume of these passages holding air which must be re-breathed is known as the anatomical dead air space. Similarly, when a mask is worn the facepiece chamber and any other parts of the air passage common to inspiration and expiration become additional dead air space contributing a further dilution of oxygen content and contamination by carbon dioxide of the inspired air in addition to that occasioned by the anatomical dead space, which of course, is always present and is taken care of by the functions normally controlling respiration. Major R. G. Pearce who directed a large amount of the research along this line, sums up the harmful effects of thus increasing the dead air space as follows: 1. Interpretation from the physiological standpoint: (_a_) A larger minute-volume of air is required when breathing through dead air space. This, interpreted on physiological grounds, means that the carbon dioxide content of the arterial blood is higher than normal. The level to which the content of carbon dioxide in the arterial blood may rise is limited. Anything which wastefully increases the carbon dioxide level of the blood decreases the reserve so necessary to a soldier when he is asked to respond to the demand for exercise which is a part of his daily life. (_b_) A larger minute-volume of air must be pulled through the canister, which offers resistance proportional to the volume of air passing through it. If resistance is a factor of harm, dead air space increases that harm, since dead air space increases the volume of air passing through the canister.