Six stalwart sons grew up under Philippa's watchful eye, to bear their father's name and maintain the honour of his house. The eldest, Antoine, succeeded René as Duke of Lorraine and Bar, and the second, Claude, became a naturalized French subject, and inherited the family estates in France, including Joinville, Guise, and Aumale. Both Princes were educated at the French Court, where Claude became the friend and companion of the future King Francis, and in 1513 married Antoinette de Bourbon, the Count of Vendôme's daughter. This lovely maiden was brought up with her cousins, Louis XII.'s daughters, the elder of whom married Francis of Angoulême, the heir to the Crown. When, in 1515, this Prince succeeded his father-in-law on the throne, he promised the young Duke of Lorraine the hand of Louis XII.'s widow, Mary of England; but the fair Dowager had already plighted her troth to Brandon, Duke of Suffolk, and Antoine consoled himself with another Princess of the blood royal, Renée de Bourbon, daughter of Gilbert de Montpensier and Chiara Gonzaga. The wedding was celebrated at Amboise on the 26th of June, 1515, and Antoine and Claude both left their brides in Lorraine with Queen Philippa while they followed Francis to Italy. There they fought gallantly by the King's side at Marignano. Antoine was knighted on the field of battle, while Claude received a dangerous wound, and a third brother was slain in the mêlée. Two of Philippa's younger sons lost their lives in the French King's later campaigns. One was killed at Pavia, and Louis, the handsomest of all his handsome race, died of the plague in Lautrec's army before Naples. A sixth son, Jean, Bishop of Metz, was made a Cardinal at twenty, and, like his brother, Claude of Guise, became a prominent figure at the French Court.