The crime of poisoning is essentially one which will be most prevalent in a high state of civilization, when the spread of scientific knowledge places nefarious means at the disposal of many, instead of limiting them, as in the days of the Borgias and Brinvilliers, to the specially informed and unscrupulously powerful few. The first intimation conveyed to society of the new terror which threatened it was in the arrest and arraignment of William Palmer, a medical practitioner, charged with doing to death persons who relied upon his professional skill. The case contained elements of much uncertainty, and yet it was so essential to the interests and the due protection of the public that the fullest and fairest inquiry should be made, that the trial was transferred to the Central Criminal Court, under the authority of an Act passed for this purpose, known as the Trial of Offences Act, and sometimes as Lord Campbell's Act. That the administration of justice should never be interfered with by local prejudice or local feeling is obviously of paramount importance, and the powers granted by this Act have been frequently put in practice since. The trial of Catherine Winsor, the baby farmer, was thus brought to the Central Criminal Court from Exeter assizes, and that of the Stauntons from Maidstone. Palmer's trial caused the most intense excitement. The direful suspicions which surrounded the case filled the whole country with uneasiness and misgiving, and the deepest anxiety was felt that the crime, if crime there had been, should be brought home to its perpetrator. The Central Criminal Court was crowded to suffocation. Great personages occupied seats upon the bench; the rest of the available space was allotted by ticket, to secure which the greatest influence was necessary. People came to stare at the supposed cold-blooded prisoner; with morbid curiosity to scan his features and watch his demeanour through the shifting, nicely-balanced phases of his protracted trial. Palmer, who was only thirty-one at the time of his trial, was in appearance short and stout, with a round head covered rather scantily with light sandy hair. His skin was extraordinarily fair, his cheeks fresh and ruddy; altogether his face, though commonplace, was not exactly ugly; there was certainly nothing in it which indicated cruel cunning or deliberate truculence. His features were not careworn, but rather set, and he looked older than his age. Throughout his trial he preserved an impassive countenance, but he clearly took a deep interest in all that passed. Although the strain lasted fourteen days, he showed no signs of exhaustion, either physical or mental. On returning to gaol each day he talked freely and without reserve to the warders in charge of him, chiefly on incidents in the day's proceedings. He was confident to the very last that it would be impossible to find him guilty; even after sentence, and until within