For several centuries before the era of modern pharmacopœias the Antidotary of Nicolas Myrepsus was the standard formulary, and from this the early dispensatories were largely compiled. This Nicolas, who was not the Nicolas Praepositus of Salerno, is sometimes named Nicolas Alexandrinus. He appears to have been a practising physician at Constantinople, and as he bore the title of Actuarius, it is supposed that he was physician to the Emperor. He is believed to have lived in the thirteenth century. Myrepsus, which means ointment maker, was a name which he assumed or which was applied to him, probably in allusion to his Antidotary. This was the largest and most catholic of all the collections of medical formulas which had then appeared. Galen and the Greek physicians, the Arabs, Jews, and Christians who had written on medicine, were all drawn upon. A Latin translation by Leonard Fuchs, published at Nuremberg in 1658, contains 2,656 prescriptions, every possible illness being thus provided against. The title page declares the work to be “Useful as well for the medical profession and for the seplasarii.” The original is said to have been written in barbarous Greek. Sprengel, who has hardly patience to devote a single page to this famous Antidotary, tells us that the compiler was grossly ignorant and superstitious. He gives an instance of his reproduction of some Arab formulæ. One is the use of arsenic as a spice to counteract the deadly effects of poisons. This advice was copied, he says, down to the seventeenth century. It was Nicolas’s rendering of the Arabic word Darsini, which meant cannella, and which they so named because it was brought from China. The compounds collected in this Antidotary are of the familiar complicated character of which so many specimens are given in this volume. Many of the titles are curious and probably reminiscent of the pious credulity of the period when Myrepsus lived. There is, for example, the Salt of the Holy Apostles, which taken morning and evening with meals, would preserve the sight, prevent the hair from falling out, relieve difficulty of breathing, and keep the breath sweet. It was obtained by grinding together a mixture of herbs and seeds (hyssop, wild carrot, cummin, pennyroyal, and pepper) with common salt. The Salt of St. Luke was similar but contained a few more ingredients. A Sal Purgatorius prescribed for the Pope Nicholas consisted of sal ammoniac, 3 oz., scammony, 3 drachms, poppy seeds, 2 drachms, orris root, 3 drachms, pepper, 13 grains, one date, pine nut 25 grains, and squill 2 drachms. This might be made into an electuary with honey. Antidotus Acharistos, which means unthanked antidote, is stated to be so named because it cured so quickly that patients were not sufficiently grateful. They did not realise how bad they might have been without it.