Mithridates VI, commonly called “the Great,” King of Pontus in Asia Minor, was born 134 B.C., and succeeded his father on the throne at the age of twelve. Next to Hannibal he was the most troublesome foe the Roman Republic had to deal with. His several wars with that power occupied twenty-six years of his life. Sylla, Lucullus, and Pompey, in succession, led Roman armies against him, and gained battles again and again, but he was only at last completely conquered by the last-named general after long and costly efforts. Mithridates was a valiant soldier and a skilful general, but a monster of cruelty. He was apparently a learned man, or at least one who took interest in learning. The fable of his medicinal secrets took possession of the imagination of the Romans. They were especially attracted by the stories of his famous antidote. According to some he invented this himself; others say the secret was communicated to him by a Persian physician named Zopyrus. Celsus states that a physician of this name gave a similar secret to one of the Egyptian Ptolemies. This may have been the same Zopyrus, for Mithridates lived in the time of the Ptolemies. The Egyptian antidote was handed down to us under the name of Ambrosia. When Pompey had finally defeated Mithridates he took possession of a quantity of the tyrant’s papers at Nicopolis, and it was reported that among these were his medicinal formulas. Mithridates meanwhile was seeking help to prosecute the war. But his allies, his own son, and his soldiers were all tired of him. In his despair he poisoned his wife and daughters, and then took poison himself. But according to the legend, propagated perhaps by some clever advertising quacks in Rome, he had so successfully immunised his body to the effects of all poisons that they would now take no effect. Consequently he had to call in the assistance of a Gallic soldier, who despatched his chief with a spear. The story of his defeat and death are historic; the poison story is legend which, however it was originated, was no doubt good value in the drug stores of Rome, where the confection of Mithridates was soon sold. As will be stated immediately there is abundant reason to believe that the alleged formula which Pompey was said to have discovered and to have had translated was devised at home.