The Earl of Warwick from whom the powder acquired its name was Robert Dudley, son of the famous Earl of Leicester, Queen Elizabeth’s favourite, and of Kenilworth notoriety. His mother was the widow of Lord Sheffield, and there was much dispute about the legitimacy of the child, but the evidence goes to show that Leicester married her two days before the birth of the boy. He afterwards abandoned her, but he left his estates to the boy. Young Robert Dudley grew up a singularly handsome and popular youth. He led an adventurous life, voyaging, exploring, and fighting Spanish ships. He failed to establish his claims to his titles and estates in England, and ultimately settled at Florence, where he became a Catholic, and distinguished himself as an engineer and architect. He won the favour of Ferdinand II, Emperor of Austria, who created him Earl of Warwick and Duke of Northumberland, and the Pope recognised his nobility. He died in Italy in 1649. The chroniclers of the time refer to a book he is said to have written under the title of _Catholicon_, which was “in good esteem among physicians.” If it existed it was probably a collection of medical formulæ, but it is not unlikely that this supposed book has been confused with one written by a Dr. Cornacchini, of Pisa, and dedicated to Dudley. In that work, which is known, the powder is described, and its invention is attributed to the Earl. It is alleged to have possessed marvellous medicinal virtues. DUKE OF PORTLAND’S GOUT POWDER. Under this title a powder had a great reputation about the middle of the eighteenth century, and well on into the nineteenth century. The powder was composed of aristolochia rotunda (birthwort root), gentian root, and the tops and leaves of germander, ground pine, and centaury, of each equal parts. One drachm was to be taken every morning, fasting, for three months, and then ½ drachm for the rest of the year. Particular directions in regard to diet were given with the formula.