The cordial then consisted of forty roots, seeds, herbs, etc., macerated in spirit of wine, and distilled. With the distillate were combined bezoar stones, pearls, coral, deer’s horn, amber, musk, antimony, various earths, sugar, and much besides. Vipers’ flesh, with the heart and liver, and “mineral unicorn” were added later on the suggestion of Sir Kenelm Digby. The official history of this strange concoction is appended. Confectio Raleighana was first official in the London Pharmacopœia of 1721. The formula was-- Rasurae C. Cervi lb. i. Carnis viperarum c. cordibus et hepatibus, 6 oz. Flor. Borag., rosmar., calendulae, roris solis, rosarum rub., sambuci, ana lb. ss. Herb. scordii, cardui benedicti, melissæ, dictamni cretici, menthæ, majoranæ, betonicæ, ana manipules duodecim. Succi Kermis, Sem. card. maj., cubebarum, Bacc. junip., macis, nuc. mosch., caryoph., croci, ana 2 oz. Cinnam. opt., cort. lign. sassaf., cort. flav. malorum citriorum, aurantiorum, ana 3 oz. Lign. aloes, sassafras, ana 6 oz. Rad. angelic., valerian, sylvest., fraxinell, seu dictamni alb., serpentar. Virginianæ, Zedoariæ, tormentillæ bistort, Aristoloch. long., Aristoloch. rotund., gentianæ, imperatoriæ, ana 1½ oz. These were to be cut up or crushed, and a tincture made from them with rectified spirit. The tincture was to be evaporated in a sand-bath, the expressed magma was then to be burned, and the ashes, lixiviated in water, were to be added to the extract. Then the following powders were to be added to this liquid to form a confection:--Bezoar stone, Eastern and western, of each 1½ oz.; Eastern pearls, 2 oz.; red coral, 3 oz.; Eastern Bole, Terra Sigillata, calcined hartshorn, ambergris, of each 1 oz.; musk, 1½ drachms; powdered sugar, 2 lb. In the P.L. 1746 Confectio Raleighana appears as Confectio Cardiaca. It is expressly stated that this new name is substituted for the old one. The formula is simplified, but the resemblance to the original can be traced. It runs thus:--Summitatum Rorismar, recent., Bacc, Junip., ana lb. i; Sem. card., min. decort., Zedoariæ, Croci. ana lb. ss. Make a tincture with these with about 1½ gallons of diluted spirit, and afterwards reduce it to 2½ lb. by evaporating at a gentle heat; then add the following, all in the finest powder:--Compound powder of crabs’ shells, 16 oz. This was prepared powder of crab shells, 1 lb.; pearls and red coral, of each 3 oz.; cinnamon and nutmegs, of each 2 oz.; cloves, 1 oz.; sugar, 2 lb. To make a confection.