was first inserted in the P.L. 1721, under the title of “Spiritus Salis Volatilis Oleosus.” Cinnamon, mace, cloves, citron, sal ammoniac, and salts of tartar were distilled with spirit of wine. In 1746 the process was altered, sal ammoniac and fixed alkali being first distilled with proof spirit to yield “spiritus salis anmioniaci dulcis,” to which essential oils of lemon, nutmeg, and cloves were added, and the mixture was then re-distilled. In 1788 the spirit became spiritus ammoniæ compositus, and the redistillation when the oils had been added was omitted. The name spiritus ammoniæ aromaticus was first adopted in the P.L. 1809, and has been retained ever since, though the process of making it has been frequently varied. That title was first given to it in the Dublin Pharmacopœia of 1807. Spiritus Salinus Aromaticus was the first title adopted in the Edinburgh Pharmacopœia. It was a preparation similar to that of the P.L., but angelica, marjoram, galangal, anthos flowers, orange, and lemon were additional flavours. Quincy (1724) credits Sylvius with the invention of this spirit, which he refers to as “mightily now in use,” and as “a most noble cephalic and cordial.” It had “almost excluded the use of spirit of hartshorn.” This preparation, invented by Sylvius, was called the Carminative Spirit of Sylvius. Mindererus’s Spirit, made from distilled vinegar and the volatile spirit of hartshorn, is believed by many competent authorities to have possessed virtues which are not contained in the modern liquor ammonii acetati. The late Professor Redwood was one of these. He believed that the old preparation contained a trace of cyanic ether. The new liquor, he said, made from strong caustic solution of ammonia and strong acetic acid, “is but the ghost of the old preparation. It is as unlike the true Mindererus’s Spirit as a glass of vapid distilled water is unlike the sparkling crystal water as it springs from a gushing fountain” (_Pharm. Jnl._, Vol. V., N.S. p. 408). Mindererus was a physician of Augsburg who died in 1621. It was Boerhaave in 1732 who advocated the use of Mindererus’s Spirit and made it popular.