Chronicles of Pharmacy, Vol. 1 (of 2)Wootton, A. C.
History
Chronicles of Pharmacy, Vol. 1 (of 2)
Wootton, A. C.
Pharmacy -- History
The crystalline protoxide of antimony obtained by inflaming,
volatilising, and condensing the regulus was known as argentine flowers
of antimony. The regulus heated with nitric acid yielded a compound of
metal with antimonious acid, and was called mineral bezoar; a compound,
really a suboxide, got by fusing sulphide of antimony and nitre was
called diaphoretic antimony; the chloride, first made by distilling
crude antimony (the native sulphide) with corrosive sublimate, yielded
the thick soft butter of antimony; the addition of water to this
chemical caused the precipitation of a white oxychloride which was
long known as Algaroth’s powder, or mercury of life. It contained no
mercury, but was the most popular emetic before the introduction of
the tartrate. Victor Algarotti, who introduced it, was a physician, of
Verona, who died in 1603. It was alleged that he was poisoned by his
local rivals in consequence of the success of his remedy. He was also
the inventor of a quintessence of gold.
The regulus of antimony in alloy with some tin was used to make the
antimony cups from which antimonial wine originated. It was also made
into the pilulæ perpetuæ, or everlasting pills, which, passing through
the body almost unchanged, were kept as a family remedy and taken
again and again. It is probable that the surface of these pills became
slightly oxidised, and consequently acquired a medicinal effect.
KERMES MINERAL.
One of the most famous of the antimony compounds was the kermes
mineral, which it is understood was invented by Glauber about 1651. He
made it by treating a solution of the oxide of antimony with cream of
tartar, and then passing a current of sulphuretted hydrogen through
the solution. An orange-red powder was obtained, and famous cures were
effected by it. Glauber kept his process secret, but a Dr. de Chastenay
learnt it after Glauber’s death from one of his pupils and confided
it to a surgeon named La Ligerie, who in his turn communicated it to
Brother Simon, a Carthusian monk, who at once commenced successfully to
treat his brother monks with it, and soon after the Poudre des Chartres
was one of the most popular remedies in France for many serious
diseases, small-pox, ague, dropsy, syphilis, and many others. In 1720
Louis XIV bought the formula for its preparation for a considerable
sum from La Ligerie. It has been agreed by chemists, Berzelius and
others, who have studied Kermes Mineral, that it is a mixture of about
40 per cent. or less of oxide of antimony with a hydrated sulphide of
the metal, and a small proportion of sulphide of sodium or potassium
(according to the method of preparation). It is still official in the
Pharmacopœias of the United States and of many Continental countries.
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