Christopher Glaser, pharmacien at the court of Louis XIV, who subsequently had to leave France on suspicion of being implicated in the Brinvilliers poisonings, was the first to make nitrate of silver in sticks. TIN. Tin came into medical use in the middle ages, and acquired its position particularly as a vermifuge. For this purpose tin had a reputation only second to mercury. Several compounds of this metal were popular as medicines both official and as nostrums in the seventeenth and eighteenth centuries, and tin did not drop out of medicinal employment until early in the nineteenth century. The beautiful mosaic gold (aurum musivum), a pet product with many alchemists, was probably the first tin compound to be used in medicine. It was made by first combining tin and mercury into an amalgam, and then distilling this substance with sulphur and sal ammoniac. It is now known to be a bisulphide of tin. The mercury only facilitates the combination of the tin and the sulphur, and the sal ammoniac has the effect of regularising the temperature in the process. The product is a beautiful golden metal of crystalline structure and brilliant lustre. It was given in doses of from 4 to 20 grains; was sudorific and purgative; and was recommended in fevers, hysterical complaints, and venereal disorders. The subsequent preparations of tin which came to be used principally as vermifuges were the Calx Jovis (the binoxide), the sal Jovis (sometimes the nitrate and sometimes the chloride), and the Amalgama Jovis. These, however, were all ultimately superseded by the simple powder of tin given either with chalk, sugar, crabs’ eyes, or combined with honey or some conserve. The dose was very various with different practitioners. Some prescribed only a few grains, others gave up to a drachm, and Dr. Alston, an eminent Edinburgh physician in the eighteenth century, said its success depended on being administered in much larger doses. He recommended an ounce with 4 ounces of treacle to be given on an empty stomach. To be followed next day with ½ oz., and another ½ oz. the day after; the course to be wound up by a cathartic. The Anti-hecticum Poterii was a combination of tin with iron and antimony, to which nitrate of potash was added. It was sudorific and was thought to be especially useful in the sweats of consumption and blood spitting. Flake’s Anti-hæmorrhoidal Ointment was an amalgam of tin made into an ointment with rose ointment, to which some red precipitate was added. Brugnatelli’s Poudre Vermifuge was a sulphide of tin. Spielman’s Vermifuge Electuary was simply tin filings and honey. Oxide of tin is the basis of certain applications for the finger nails. As supplied by perfumers the pure oxide is coloured with carmine and perfumed with lavender. Piesse says pure oxide of tin is similarly used to polish tortoiseshell. ZINC.