The sorcery practised so largely in the Middle Ages must have frequently developed into poisoning. The philtres were to a large extent the same as those which the Romans had used. Opium, belladonna, datura, _Cannabis Indica_, and arsenic were capable of producing astonishing effects, and there was but little chance of detection except the chance which was just as likely to result in the conviction of an innocent as a guilty person. Poisons, or at least the terror of them, played a considerable part in the history of Italy in the fifteenth and sixteenth centuries, and the country acquired the nickname of Venenosa Italia. Even earlier the famous Venetian “Council of Ten” was believed to have made a systematic business of assassination by poison. It employed experts and had a regular tariff--so much for a king, so much for a duke and downwards, which was allowed, plus expenses. The crime having been accomplished, the books of the Council recorded the fee, and the single word “factum” was added. The Medicis and the Borgias, and other of the great aristocrats of the nation are supposed to have kept skilled poisoners in their pay. Giambaptista Porta, Mercurialis, and other scientific men wrote treatises on toxicology as it was understood at the period, coloured with exaggerated fancies such as would impress the common public, and tempt the criminally inclined. Porta, for example, describes the “magic unction” which witches were believed to employ. It was this which gave them power to fly through the air. He attributes this virtue to belladonna. With dulcamara they made a drugged cheese which they gave to travellers, and which had the effect of inducing the victims to fancy themselves beasts of burden. In this condition the adepts could set them to any work they wanted done, and, this performed, they gave them an antidote which restored them to their proper senses. CREDULITY IN REGARD TO POISONS. Terror of poisons became epidemic in many countries, and eager credulity welcomed any alleged antidote. Ambrose Paré relates an incident in which he was an actor. He, a Protestant, was principal physician to Charles IX, the wretched author of the Massacre of St. Bartholomew. His story of the experiment which that king had made with a bezoar stone is related on page 18. There was also an Archduke Ferdinand of Austria who in the same century invented an antidote to poisons. It was composed of sapphire, hyacinth, emerald, ruby, and garnet. He also, according to Matthiolus, tried an experiment similar to the one narrated by Paré. A Bohemian, condemned to be hanged, was given 2 grains of arsenic. In four hours he had become livid, prostrate, and apparently dying. He was given a dose of Ferdinand’s powder in a glass of white wine, and recovered. Matthiolus also states that Pope Clement VII made such experiments on condemned criminals.