The monumental instance of official ingratitude was, however, manifested in the case of Charles Ledger, to whom, more than to any other man, the world is indebted for cheap quinine, and out of whose adventurous services the Dutch nation have made millions in their Java dependency. Between the years 1841 and 1858 Ledger was travelling in South America in the employment of the New South Wales Government buying alpacas. He had a faithful servant, Manuel Manami, who had often told him how jealously the natives, especially those of Bolivia, guarded the knowledge of their best seeds. Manami had himself been a cascarillero or bark cutter. On Ledger’s return to Australia in 1858 he found that Holland and England were eagerly seeking to plant cinchona in their Eastern possessions. The mission of Hasskarl had been practically a failure. He had not been able to enter Bolivia, and the species he brought to Java were comparatively valueless. Ledger was in South America when Markham went there on his official journey. He endeavoured to open communication with the British Government’s envoy but failed. He, however, pressed his faithful Manami to secure some of the precious “rojo” (_Cinchona Calisaya_, var. _Ledgeriana_) seeds from Bolivia. Manami fulfilled this service, somewhat reluctantly, sent the seeds to his master, but was himself thrown into prison, beaten, and died soon after in consequence of the cruel treatment he underwent. Ledger sent the seeds to his brother in England authorising him to dispose of them as he best could. They were at first offered to the British Government, but as Markham was then in India superintending the planting of the seeds he had brought from Peru, the offer was not entertained. Half of them were sold to a Ceylon planter, and the rest were taken, after some discussion, by the Dutch Government for about £33, with a promise of a further payment if the plants flourished. A year later on a report that 20,000 plants had been raised from these seeds the Dutch Government paid Ledger a further £100 and got from him a letter expressing his satisfaction. That was in 1866.