On the tenth of November it definitely was said that, at the garden-supper of the fifth of August venom had been put into some wine by order of the Lord Alexander P.P. VI; that by a butler’s blunder that envenomed wine had been served to the Pope’s Holiness and to Duke Cesare: that the former being old had died therefrom; that the latter being young had endured heroic treatment for a cure. Some said that he had been plunged into the ripped-up belly of a live mule or bull amid the steaming palpitating entrails profusely to sweat the venom out of him: others, that he had been dipped in iced-water, and so cured. Writing several years later, Messer Francesco Guicciardini and Messer Paolo Giovio added new details. Guicciardini definitely settled the falsehood in the form in which it generally appears. He gave a list of cardinals, also, and prelates who were to have been envenomed by the Lord Alexander P.P. VI that He might inherit their wealth. Giovio named and described the venom which, he said, the Borgia commonly used. He called it _Cantarella_[64]; and said it was a sugared powder, or a powder under the guise of sugar, which was of a wonderful whiteness, and of a rather pleasant taste. It did not overwhelm the vital forces in the manner of the active venoms by sudden and energetic action: but, by penetrating insensibly the veins, it slowly worked with mortal effect. (Paolo Giovio, Hist. II. 47. VIII. 205.) Is there any toxicological chymist who from this description can give the formula of this extraordinary venom?