Reverting to the Senior Branch:— The career of Don Francisco de Borja, bastard of Bishop Alonso de Borja of Valencia (afterwards the Lord Calixtus P.P. III), is an unsolved mystery from his birth in 1441 until 1497.... Of the five children of Doña Juana de Borja by her husband Don Jofre de Lançol:— (α) Doña Francisca married Don Ximenez Perez de Arenas; (β) Doña Tecla married Don Vitale de Villanueva; (γ) Doña Juana married her cousin Don Guillelmo de Lançol, and had issue:— Girolama, Angela, Pedro Luis (Pierludovico).... Juan (Giovanni seniore).... (δ) Don Rodrigo, Vicechancellor-Cardinal-Deacon of San Niccolo _in Carcere Tulliano_.... (ε) Don Pedro Luis, Duke of Spoleto, Castellan of Santangelo, Prefect of Rome, died on the twenty-sixth of September 1458, leaving two bastards:— Juan (Giovanni giuniore).... Silvia, married Don Alonso Gomiel. Of the two children of Doña Caterina de Borja by her husband Don Juan de Mila, Baron of Mazalanes:— (α) Don Luis Juan, Cardinal-Presbyter of Santi Quattro Coronati, Bishop of Lerida, retired to his diocese on the death of his August Uncle and Creator, and lived there secluded till his death in 1507. (The career and character of this prince of the church, cardinal at twenty, bishop at twenty-three, and during those three years living in the very arcana of the pontifical court; who then thought fit to bury himself in a remote university city during half a century, while his nearest kin were ruling Europe and Christendom, awaits, and should repay, investigation.) (β) Doña Adriana came to Italy, married Don Luigi Orsini, and had issue Don Orso Orsini.... * * * * * The chief personage of the House of Borja, on the death of the Lord Calixtus P.P. III, was Cardinal Rodrigo, of the age of twenty-seven years. His position was a precarious one; and it is perfectly amazing that he was not forced to follow his cousin, the Cardinal de Mila, into permanent retirement. That he was able, not only to remain in Rome but to carve out for himself a unique career there, undoubtedly is due to those superb talents and alert vigour of character which have made him such a prominent figure in history.