Milan menaced the peace of Italy. By the assassination of Duke Galeazzo Maria Sforza-Visconti in 1476, the duchy passed to his infant son Duke Giangaleazzo; whose widowed mother, the Duchess Bona of Savoja, ruled as Regent. Four brothers of her dead husband conspired against her; and in 1479, the eldest, Don Ludovico Maria Sforza-Visconti (detto Il Moro), took possession of her child and deprived her of the regency. Cardinal Ascanio Maria, brother of Il Moro, exerted himself in Rome to obtain confirmation of this heartless deed. Duchess Bona, distracted when she found her young son torn from her arms, knowing his infant life to be the only bar between his uncle Don Ludovico Maria and the throne of Milan, made frantic appeals for the intervention of France. But the Christian King Louis XI died before he could reply to that poor mother: and Don Ludovico Maria, as Regent, thrived, keeping the boy-duke at Pavia in a palace that was, in fact, a prison, in conditions not cruel nor fatal but assuredly not ducal, nor suited to the enjoyment and maintenance of life. In 1489 Duke Giangaleazzo reached the age of twenty years; and then it was remembered that his mother; the Duchess Bona, had affianced him in his infancy to Madonna Isabella, daughter of the heir of Naples, Duke Don Alonso de Aragona of Calabria. There appeared to be no reason why Don Ludovico Maria should exacerbate the royal House of Naples by interference with the keeping of this contract; the boy was eager, the girl was marriageable; and the wedding was celebrated with appropriate pomp. The usurping Regent insisted, however, that, as the young Duke was a minor, he should still remain in the condition of a ward; and the newly-wedded children retired to try conjugal life at Pavia. A year later, 1492, a son was born; and then Duke Giangaleazzo, by paternity emboldened into manlihood, became restive against his uncle’s yoke, protesting that he no longer would submit to the treatment of a boy. But Don Ludovico was well aware that long confinement shortens life; and he had kept his nephew a prisoner for ten years. He was not precisely of the stuff of which murderers are made; or a knife-blade delicately pushed between the youngster’s neck and spine long ago would have made the sceptre of Milan his. As Regent he had absolute power; and he was well content to wait. So he took no notice of Duke Giangaleazzo’s remonstrances; and, to pass the time, he practised marriage in his proper person, wedding the lovely Madonna Beatrice d’Este of Ferrara in 1491. (Don Francesco Sforza, son of Don Bosio Sforza and Madonna Cecilia Aldobrandeschi, heiress of Santafiora, the kinsman of Don Ludovico Maria, who arranged this marriage, was the Orator of Milan at the coronation of the Lord Alexander P.P. VI in 1492.) After the nuptials of the usurping Regent, the young Duke Giangaleazzo resigned himself to bear his lot. But his wife was furious, and thought of the interests of her baby son.