Set apart to the work by the church by prayer and laying on of hands, Paul and Barnabas started from Antioch on their =first= missionary journey to Asia Minor, A.D. 48-50. Notwithstanding much opposition and actual persecution on the part of the enraged Jews, he founded mixed churches, composed principally of Gentile Christians, comprising congregations at Antioch in Pisidia, Iconium, Lystra, and Derbe. When Paul undertook his =second= missionary journey, A.D. 52-55, Barnabas separated himself from him because of his refusal to accept the company of his nephew John Mark, who had deserted them during their first journey, and along with Mark embarked upon an independent mission, beginning with his native country Cyprus; of the success of this mission nothing is known. Paul, on the other hand, accompanied by Silas and Luke, with whom at a later period Timothy also was associated, passed through Asia Minor, and would thereafter have returned to Antioch had not a vision by night at Troas led him to take ship for Europe. There he founded churches at Philippi, Thessalonica, Berea, Athens, and Corinth, and then returned through Asia Minor to Syria. Without any lengthened interval he entered upon his =third= missionary journey, A.D. 55-58, accompanied by Luke, Titus, and Timothy. The centre of his ministerial activity during this period was Ephesus, where he founded a church with a large membership. His success was extraordinary, so that the very existence of heathenism in Asia Minor was seriously imperilled. Driven away by the uprising of a heathen mob, he travelled through Macedonia, pressed on to Illyricum, visited the churches of Greece, and then went to Jerusalem, for the performance of a vow. Here his life, threatened by the excited Jews, was saved by his being put in prison by the Roman captain, and then sent down to Cæsarea, A.D. 58. An appeal to Cæsar, to which as a Roman citizen he was entitled, resulted in his being sent to Rome, where he, beginning with the spring of A.D. 61, lived and preached for several years, enduring a mild form of imprisonment. The further course of his life and ministry remains singularly uncertain. Of the later labours and fortunes of Paul’s fellow-workers we know absolutely nothing.