As soon as the method for the vaccination of dogs was firmly established, and we had in our possession a large number of dogs which had been rendered refractory to rabies, I had the idea of submitting to a competent committee those of the facts which appeared destined in future to serve as a basis for the vaccination of dogs against rabies. That course was suggested to me in prevision of the later practical application of the method, by the recollection of the opposition with which Jenner’s discovery met at its beginning. I spoke of my project to M. Fallières, the Minister of Public Instruction, who was pleased to approve of it and gave commission to the following gentlemen to control the facts which I had summarily communicated to the Academy of Sciences in its sitting of May 19 last: Messrs. Béclard, Paul Bert, Bouley, Aimeraud, Villemin, Vulpian. M. Bouley was appointed president, Dr. Villemin, secretary, and the commission at once set to work. I have the pleasure of informing you that it has just sent in a first report to the Minister. I was acquainted with it here, and the following are in a few words, the facts related in that first report on rabies. I had given to the commission nineteen vaccinated dogs in succession--that is to say, dogs which had been rendered refractory by preventive inoculations. Thirteen only of them had after their vaccination been already submitted to the test-inoculation on the brain. The nineteen dogs were, for the sake of comparison, divided into sets along with nineteen more control dogs brought from the pound without any sort of selection. To begin with, two refractory dogs and two control dogs were on June 1 trephined and inoculated under the dura-mater, on the surface of the brain, with the bulb of a dog affected with ordinary street rabies. On June 3 another refractory dog and another control dog were bitten by a furious street mad dog. The same furious mad dog was on June 4 made to bite still another refractory and another control dog. On June 6 the furious dog which had been utilised on June 3 and 4 died. The bulb was taken out and inoculated, after trephining, into three refractory dogs and three control dogs. On June 10 another street mad dog, having been secured, was, by the commission, made to bite one refractory and one control dog. On June 16 the commission had two new dogs, a refractory one and a control one, bitten by one of the control dogs of June 1, which had been seized with rabies on June 14 in consequence of the inoculation after trephining which it had received on June 1. On June 19 the commission got three refractory and three control dogs inoculated before their own eyes in the popliteal vein with the bulb of an ordinary street mad dog. On June 20 they had inoculated in their presence, and still in a vein, ten dogs altogether, six of them refractory and four just brought from the pound.